location_onOxford, UK
watch_later Posted: Feb 14, 2024
Skills Required
Nice To Have skills
Job Description
Description
About Us
Exscientia is an AI-driven pharmatech company committed to discovering, designing and developing the best possible drugs in the fastest and most effective manner. Exscientia developed the first-ever functional precision oncology platform to successfully guide treatment selection and improve patient outcomes in a prospective interventional clinical study, as well as to progress AI-designed small molecules into the clinical setting.
Our pipeline demonstrates our ability to rapidly translate scientific concepts into precision-designed therapeutic candidates, with more than 15 projects underway. By designing better drugs, faster, we believe the best ideas of science can rapidly become the best medicines for patients.
The Role
- We are expanding our in vitro cancer cell biology capabilities at our new state of the art laboratories in Milton Park and are seeking experienced, motivated, and dynamic individuals to join the primary pharmacology team. This team provides critical data driving our drug discovery projects and is in charge of conceiving, developing, and executing cellular assays for a range of target classes, often in areas of novel biology.
- Successful applicants will be given the freedom to design, plan and execute a variety of experiments ensuring that the assays are fit-for-purpose, and that data is appropriately quality-controlled. In our newly built laboratories, we have access to a wide array of assay technologies (FRET, luminescence, FACs, imaging) with automation capabilities and are continually striving to deploy the latest technologies and develop ever more efficient processes.
- Please note this is an on-site role at our Milton Park site in Oxford, with occasional flexibility to work from home in the UK. We are a flexible working organisation and we’re willing to consider other options which would provide similar contact time with the team.
You will have the opportunity to:
Develop assays to help drive development of therapeutic small molecules with a focus on compound characterisation and the rapid identification of candidate molecules in the oncology area.
You will be expected to keep up with the latest scientific developments, evaluate new technologies and will have the opportunity to present both internally and externally.
This is primarily a laboratory-based positions with scope for continual learning and development and exposure to all scientific disciplines within the drug discovery process from target validation to candidate selection.
Requirements
- Ph.D in Oncology, Biology, Pharmacology, or a related discipline or a BSc/MSc degree with significant relevant experience, preferably in the pharmaceutical or biotechnology industry.
- Sterile techniques and cell culture
- In vitro assay development and assay optimisation
- Experience of cell-based assays such as proliferation, cell binding, cytokine release, and tumour killing
- Practical knowledge of a wide range of assay technologies such as FRET, flow cytometry and imaging
- Experience of screening and data analysis including dose-response relationships
- Flexible, adaptable, and able to work across multiple projects.
- Excellent interpersonal and communication skills, both written and verbal, with ability to communicate technical information to a non-specialist audience.